Transported systemically from the gut via specific binding proteins, cholecalciferol travels first to the liver for conversion to 25-hydroxycholecalciferol (calcifediol) and then to the renal tubules for conversion to 1,25-dihydroxycholecalciferol (calcitriol)
Physiology and Calcium-Regulating Hormones in Dogs and Cats
Although hypercalcemia reportedly occurs in 30% to 57% of humans treated with
Canine
Key points
Circulating concentrations of total calcium, iCa, and calcitriol and the FEP did not differ between groups, whereas the serum 25‐ (OH)D concentrations were lower
Calcitriol adds in its own effects: Calcitriol enhances calcium absorption from food
Calcitriol is the active metabolite and increases intestinal absorption of calcium, stimulates bone resorption of calcium and increases renal tubular reabsorption of
Please consult your veterinarian if you have any questions
Calcitriol supplementation in dogs and cats with CKD has several beneficial effects
The goal is to maintain a bicarbonate (TCO2) level between 18 and 25 mmol/L
Vitamin D metabolism seems unaffected in a small cohort of 12 dogs with PDH, in which 25‐(OH)D, calcitriol, and 24,25‐(OH)D do not differ as compared to healthy dogs
Because calcium carbonate contains 40% elemental calcium, one 750 tablet contains 300 mg of calcium, so a cat would need approximately 3 tablets daily for calcium supplementation
Maintenance dose: 0
Comments: In dogs and cats with anemia secondary to CRF, the initial dosage of r-HuEPO is 50-100 units/kg subcutaneously (SQ) three times a week
In this use, it is often administered with calcium supplements to the diet
This web site provides information for veterinarians and pet owners considering the use of calcitriol to treat dogs and cats with chronic renal failure (CRF)
• Calcitriol-mediated hypercalcemia-physiologic consequences of elevated active vitamin D 3 includes:-Enhanced intestinal resorption of calcium-Synergism with PTH to enhance osteoclast maturation and activity resulting in greater bone resorption
Common signs of poisoning may not be evident for 1-3 days, when the The major minerals that are measured in chemistry testing are calcium (total and free ionized), phosphate and magnesium
Pets with abnormally low calcium levels often show signs The oral LD 50 of cholecalciferol in dogs is 10-88 mg/kg and signs of poisoning can occur after ingestion of 0
Dogs with PHPT tend to have mild clinical signs in general, but can sometimes be quite sick at presentation
Calcitriol capsule can be administered orally as a capsule (0