Sep 29, 2023 · Considering that vitamin K is essential for the γ-carboxylation of these proteins, warfarin could control the functions of these proteins and subsequently lead to low BMD and osteoporosis
Long-term warfarin therapy might be associated with the high risk of osteoporosis and ectopic calcification in vasculature or heart valves
Vitamin K-dependent matrix
In contrast, a retrospective observational study of Medicare recipients with atrial fibrillation found that elderly patients who received warfarin long-term (≥ 1 year)
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Bone remodeling is held in check by osteocyte secreted sclerostin, a Wnt inhibitor that prevents bone formation by osteoblasts, until osteocytes sense bone stress or