IV C
Digoxin toxicity is characterised by gastrointestinal distress, hyperkalemia and life-threatening dysryhthmias, including increased automaticity and AV nodal blockade
With intravenous use: Avoid rapid intravenous administration (risk of hypertension and reduced coronary flow)
Contraindicada en casos de hipersensibilidad a la digoxina, intoxicación digitálica, fibrilación ventricular
The onset of action occurs 30 minutes to 2 hours after oral ingestion and 15 to 30 minutes after intravenous administration []
In this work, pharmacology and toxicology of digoxin Challenges for the Basis of Practice will be a regular feature of Circulation: Heart Failure (see Stevenson LW
Digoxin Derived from the purple foxglove plant, Digoxin was first used to treat heart complaints 200 years ago
A Digoxina tem actividade positiva cronotrópica e inotrópica negativa
Esta alteração leva A greater concentration of cytosolic Ca 2+ then occurs inside the cell with digoxin, thereby allowing for a greater degree of binding to troponin C and eventually myosin/actin binding thus allowing for a greater force of contraction (or inotropy)
Los efectos de la digoxina derivan tanto de sus acciones directas sobre el miocardio, como de acciones indirectas sobre el sistema cardiovascular Drugs that increase effect of digoxin: Amiodarone
125-0
125 mg/day) in patients with impaired renal function or low lean body mass
Digoxin reduces SNS activation & increases parasympathetic activity leading to a decrease in heart rate, thus enhancing diastolic flling
La bomba de sodio-potasio, o K-pump, implica el bombeo de potasio